Anti Estrogen / Gynecomastia

Estrogen is often thought of as a female hormone, as the ovaries produce much of the hormone. However, men also have estrogen in their bodies. About 20% of a man's estrogen is produced by the testes. The rest is produced in body fat, the brain, skin, and bones.

Symptoms of Estrogen and Testosterone Imbalance

Changes to the ratio of estrogen and testosterone in the body can result in health problems for some people. For example, in people with late-onset hypogonadism, lower testosterone levels and an increase of androgens being converted to estradiol is associated with a number of health issues, including:

Infertility
Reduced sex drive
Reduced muscle mass and energy
Erectile dysfunction


Hot flashes
Decreased testicle size
Gynecomastia

   

Aromatase excess syndrome is a rare genetic condition that results in higher levels of estrogen. It can affect some young men and lead to late childhood developmental symptoms. In addition to breast growth, the associated symptoms include:

Medications

Medications used as estrogen blockers include:

Aromatase inhibitors (AI): This medication can increase testosterone, along with other hormones, by inhibiting the ability of androgens to be converted to estradiol in the body. This decreases the overall level of estrogen in the body. The medication also acts on the hypothalamus and pituitary gland to increase luteinizing hormone

(LH) and follicle-stimulating hormone (FSH) in the body, which may support healthy sperm. Some available AI medications used for this purpose are anastrazole and letrozole.

Selective estrogen receptor modulators (SERM): These medications bind to estrogen receptors to prevent estrogens from binding with each other. A similar function of releasing LH and FSH can also be achieved by use of SERM. Common SERM medications used to address the hormonal balance in men include tamoxifen
and clomiphene citrate.